Cannabinoid Clinic: CBC

Updated: Nov 15

Welcome to Cannabinoid Clinic, an education project powered by Higher Learning LV. This series provides cannabis and hemp industry professionals with easily digested cannabinoid profiles that ask little of your time—but provide plenty of science-based information.


There are two categories of cannabinoids: Phytocannabinoids and endocannabinoids. Phytocannabinoids are those produced by cannabis/marijuana/hemp, while endocannabinoids are made by the human body. This series covers both.

CBC molecular structure


What is CBC?

Cannabichromene (CBC) is the result of CBCA, the acidic precursor for this particular cannabinoid. Interestingly, CBC is considered both a major and minor cannabinoid due to its commonality (it is present in most cannabis and hemp cultivars) and because it is typically present in volumes of under one percent, respectively. Although not psychoactive, anecdotal testimonies and scientific research has revealed that CBC may help patients suffering from pain, depression, and the various outcomes of inflammation.


"CBC is special because it helps prevent the breakdown and degradation of endocannabinoids such as anandamide and 2-AG."

First isolated in 1966 by Dr. Raphael Mechoulam and Y. Geoni in Israel, CBC is special because it helps prevent the breakdown and degradation of endocannabinoids such as anandamide and 2-AG. These cannabinoids, in turn, can decrease depression and lower pain. Thus, CBC has an indirect positive outcome on symptoms such as major depressive disorder and pain experienced by millions of patients.


CBC Fast Facts

  • Role: Results from CBCA

  • Biosynthetic pathway: CBGA > CBCA > CBC > CBL

  • Psychoactivity: Non-psychoactive

  • Acidic precursor: CBCA

  • Boiling point: 428° F

  • Primary medical benefits: Anti-inflammatory, analgesic, antidepressive


Biosynthetic pathway of CBC


CBC Medicinal Benefits

The primary potential medicinal benefits of CBC are found in its anti-inflammatory and pain fighting properties. However, rodent studies have demonstrated antibacterial and antifungal capabilities. In addition, this cannabinoid may be helpful for those suffering traumatic brain injuries and acne.


A 2006 study entitled "Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma" indicated that CBC may provide anti-cancer efficacy for some patients.


A 2011 study entitled "Pharmacological Evaluation of the Natural Constituent of Cannabis Sativa, Cannabichromene and its Modulation by Δ9-Tetrahydrocannabinol" revealed that CBC and THC, in combination, may produce better anti-inflammatory responses than either cannabinoid in isolation.


"A 2011 study revealed that CBC and THC, in combination, may produce better anti-inflammatory responses than either cannabinoid in isolation."

A 2013 rodent study entitled "The Effect of Cannabichromene on Adult Neural Stem/Progenitor Cells" showed that CBC had a positive effect on a particular type of brain cell called a neural stem progenitor that is essential to healthy brain function.


A 2016 study entitled "Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment" showed that CBC may be an effective treatment for acne.


How to Get CBC

Some companies sell tinctures, capsultes, and oils that feature a significant percentage of CBC. Patients can also infuse foods with loose-leaf flower that has been decarboxylated, converting the CBCA acidic precursor into CBC.


Like what you just read? Check out our new Cannabis for Cancer Hub that features links to all of our articles about marijuana for cancer.

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