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Cannabinoid Clinic: CBCA

Updated: Mar 24, 2023

This article is brought to you by the new Higher Learning LV Core Cannabis course.


Welcome to homework assignment 1.1 of the Core Cannabis Lite Track from Higher Learning LV. When you complete this assignment, simply click the link at the bottom of the article to return to the master page for this training track.


Welcome to Cannabinoid Clinic, an education project powered by Higher Learning LV. This series provides cannabis and hemp industry professionals with easily digested cannabinoid profiles that ask little of your time—but provide plenty of science-based information.

There are two categories of cannabinoids: Phytocannabinoids and endocannabinoids. Phytocannabinoids are those produced by cannabis/marijuana/hemp, while endocannabinoids are made by the human body. This series covers both.

CBCA molecular structure

What is CBCA?

Cannabichromenic acid (CBCA) is a minor cannabinoid and was first isolated in 1968 by Japanese researchers, two years following the discovery by Israeli researchers of the cannabinoid that it produces when decarboxylated, cannabichromene (CBC).

CBCA and is an acidic precursor cannabinoid that is produced by cannabigerolic acid (CBGA), another acidic precursor and a special molecule that has been dubbed the "mother of all cannabinoids." This is due to the fact that CBGA synthesizes not only cannabigerol (CBG), but also the important acidic precursors CBDA and THCA.

"Mature plants typically feature only a fraction of one percent of CBCA in dry weight by volume."

CBC is considered one of the four major cannabinoids produced by hemp and cannabis, along with cannabidiol (CBD), CBG, and tetrahydrocannabinol (THC). The volumes of CBCA peak early in the growth of a cannabis plant due to the position of this cannabinoid in the overall biosynthetic pathway of this botanical species. In fact, mature plants typically feature only a fraction of one percent of CBCA in dry weight by volume (typically 0.2-0.3 percent in most cultivars) because most of the CBCA was converted to CBC during the growth cycle of the plant.

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