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Cannabinoid Clinic: CBCV

Updated: Dec 7, 2022

Welcome to Cannabinoid Clinic, an education project powered by Higher Learning LV. This series provides cannabis and hemp industry professionals with easily digested cannabinoid profiles that ask little of your time—but provide plenty of science-based information.

There are two categories of cannabinoids: Phytocannabinoids and endocannabinoids. Phytocannabinoids are those produced by cannabis/marijuana/hemp, while endocannabinoids are made by the human body. This series covers both.

CBCV molecular structure

What is CBCV?

Cannabichromevarin (CBCV) is the varin version of cannabichromene (CBC), a cannabinoid that results from the acidic precursor cannabichromenic acid (CBCA). All major cannabinoids feature a varin version, including cannabidivarin (CBDV) and tetrahydrocannabivarin (THCV).

"From a hard research perspective, few studies have been conducted since its discovery and relatively little is understood about this cannabinoid."

CBCV, a minor cannabinoid, was discovered in 1975 at the University of Nagasaki in Thailand by researchers who first isolated it from a cannabis plant. From a hard research perspective, few studies have been conducted since its discovery and relatively little is understood about this cannabinoid. However, based on the proven behavior of more researched cannabinoid isomers, including CBD and THC, scientists believe that many of the characteristics of CBC may also exhibited by CBCV.

CBCV Fast Facts

  • Role: Results from CBCVA

  • Biosynthetic pathway: CBGVA > CBCVA > CBCV

  • Psychoactivity: Nonpsychoactive

  • Acidic precursor: CBCVA

  • Boiling point: 755° F

  • Primary medical benefits: Antiseizure

CBCV Medicinal Benefits

Compared to other cannabinoids, little research has been conducted on CBCV. The studies that exist point toward CBCV providing anti-seizure efficacy for epilepsy. This phytomolecule may also provide relief for those suffering from neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease based on benefits delivered by similar cannabinoids, including CBC and CBCA.

Because CBC and CBCV feature very similar molecular structures, many of the benefits conveyed by the former may be delivered by the latter. This includes potential reductions in anxiety and depression and anti-inflammatory benefits. CBC has also demonstrated anti-cancer efficacy and may also treat Crohn's disease and glaucoma.

The study reported that "anticonvulsant efficacy was evident with CBC, CBCA, CBCV, and CBCVA."

A January 2021 study entitled "Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome" that was published in the journal Neuroscience explored the potential anticonvulsant (antiseizure) benefits of a number of cannabinoids—including CBC, CBCA, CBCV, and CBCVA—for children suffering from Dravet syndrome epilepsy.

The study reported that "all phytocannabinoids within the CBC series were readily absorbed and showed substantial brain penetration" and that "anticonvulsant efficacy was evident with CBC, CBCA, and CBCVA."

Concluded the study's authors, "since CBC and derivatives are anticonvulsant in a [mouse] model of intractable pediatric epilepsy, they may constitute part of the mechanism through which artisanal cannabis oils are anticonvulsant in patients."

How to Get CBCV

Like many other minor cannabinoids, CBCV is not readily available in commercial volumes and accessible products in which it is a primary ingredient. In loose-leaf cannabis flower, it is most likely to appear in samples of the plant that are richest in CBC.

Some companies have begun to breed hemp cultivars featuring varin cannabinoids, including CBCV, CBDV, and CBGV.

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