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Cannabinoid Clinic: CBGVA

Updated: Mar 24, 2023

This article is brought to you by the new Higher Learning LV Core Cannabis course.


Welcome to homework assignment 1.24 of the Core Cannabis Training Track from Higher Learning LV. When you complete this assignment, simply click the link at the bottom of the article to return to the master page for this training track.


Welcome to Cannabinoid Clinic, an education project powered by Higher Learning LV. This series provides cannabis and hemp industry professionals with easily digested cannabinoid profiles that ask little of your time—but provide plenty of science-based information.

There are two categories of cannabinoids: Phytocannabinoids and endocannabinoids. Phytocannabinoids are those produced by cannabis/marijuana/hemp, while endocannabinoids are made by the human body. This series covers both.

CBGVA molecular structure

What is CBGVA?

Cannabigerovarinic acid (CBGVA) is a varin-specific acidic precursor. However, unlike other varin-specific acidic precursors—such as CBCVA, CBDVA, and THCVA—CBGVA is a "meta" acidic precursor that is responsible for creating all other varin-specific acidic precursors in the plant (including those listed above).

CBGVA is a "meta" acidic precursor that is responsible for creating all other varin-specific acidic precursors.

This minor cannabinoid was first isolated in 1977 by Japanese researchers. The neutral version of this cannabinoid, cannabigerol (CBG), was discovered in 1964 by pioneering cannabis researcher Dr. Raphael Mechoulam in Israel. While not as commercialized as cannabidiol (CBD) or tetrahydrocannabinol (THC), CBG is rapidly gaining in popularity as wellness professionals, patients, and consumers learn about this increasingly favored non-psychoactive cannabinoid.

Thus, just as the acidic precursor CBGA is considered the "mother of all cannabinoids" (all except the varins) and to act as a "stem cell" in the hemp and cannabis plants, CBGVA could be considered the mother of all varin cannabinoids, including CBCV, CBDV, CBGV, and THCV.

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