Cannabinoid Ratios

Updated: May 7

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The size of a dose of a particular cannabinoid or group (formulation) of cannabinoids determines the precise efficacy that will result from its consumption. Many consumers are unaware of the impact of the ratios in which these cannabinoids appear when consumed by humans.

According to the 2012 book, Subjective and Physiological Effects of Oromucosal Sprays Containing Cannabinoids, "The net overall effect of cannabis is thought to be related to the ratio of its composite constituents; in particular, the ratio of THC to cannabidiol (CBD)."

A 2020 study entitled "A Systematic Review of the Current Data on the THC:CBD Ratio" reported that the "ratios of THC and CBD impact metabolism and therapeutic effects of cannabis."

This study investigated all references to cannabinoid ratios in clinical studies between 2010 and 2020 and identified 479 incidences. From these, the researchers found the following ratios to be the most common: 1:0, 22:1, 2:1, 1:1, 1:2, 1:6, 1:9, 1:20, 1:33, 1:50, and 0:1.

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