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Core Cannabis Course: Anandamide

Updated: Mar 24, 2023

Welcome to homework assignment CCC 1.10 of the Core Cannabis Course from Higher Learning LV. This assignment teaches students about the endocannabinoid anandamide. This cannabinoid is involved in the maintenance of the endocannabinoid system and its overall health. Some researchers hypothesize that some cannabinoids—including THC—mimic the behavior of anandamide (likewise, the phytocannabinoid CBD is said to mimic the endocannabinoid 2-AG, the subject of the previous homework assignment).


When you complete this assignment, simply click the link at the bottom of the article to return to the master page for this course.

 

What is Anandamide?

Anandamide (also known as N-arachidonoylethanolamine or AEA) was first isolated and identified in 1992 by two independent research teams: The same Israeli researcher who isolated and synthesized delta-9 tetrahydrocannabinol (THC) in the mid-1960s, Raphael Mechoulam, and NIMH researchers William Devane and Lumir Hanus. Anandamide is one of two major endogenous (internally produced) cannabinoids that includes 2-AG.


This endocannabinoid is sometimes called the bliss molecule—its definition in Sanskrit—due to the role that it plays in the regulation of mood, emotion, and preventing depression. The naming of this molecule was an attempt by the scientists who discovered it to convey their perception of its biochemical significance to humans.

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