Updated: May 7
The cannabis/hemp/marijuana plant species produces three primary families of wellness molecules: Cannabinoids (such as CBD and THC), flavonoids (one of which is described below), and terpenes.
Apigenin is a flavonoid that has been shown to provide relaxation and, in sufficient quantities, sedation. It has also demonstrated neuroprotective and anticancer qualities and has shown promise as a potential therapeutic agent in the treatment of diseases such as Alzheimer's, depression, multiple sclerosis, and osteoporosis.
A 2019 study entitled "The Therapeutic Potential of Apigenin" that was published in the International Journal of Molecular Sciences provided an "updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions."
The study found this flavonoid to exhibit a range of positive efficacy for several disease states and conditions, including diabetes, Alzheimer's and amnesia, depression, insomnia, cancer, multiple sclerosis, and osteoarthritis.
The researchers noted the favorable safety profile of this flavonoid. "Apigenin is considered safe, even at high doses, and no toxicity has been reported." The study also observed that, at high doses, apigenin "can trigger muscle relaxation and sedation."
Along with other flavonoids, including quercetin, apigenin has also demonstrated antiviral efficacy. The study concluded that apigenin "could play a key role in the prevention and treatment of emerging global health issues."
A 2018 study entitled "Apigenin as Neuroprotective Agent: Of Mice and Men" that was published in the journal Pharmacological Research explored the ability of this flavonoid to treat "neurodegenerative disorders (NDDs) such as Alzheimer's and Parkinson's diseases," which it noted as being the most common age-related pathologies in the world for which "effective therapy...is not available," making alternative plant-based therapies of special interest to desperate patients and wellness professionals.
The researchers noted that a host of "natural products, including flavonoids, offer neuroprotection through multiple mechanisms."
Because neurodegenerative diseases such as Alzheimer's and Parkinson's diseases cause memory loss and overall cognitive decline (including emotional instability) via the death of brain cells, this study found apigenin to possibly offer value by "maintaining and enhancing the function of surviving neurons."
To learn more, subscribe to the Higher Learning LV™ Knowledgebase, the largest ad-free cannabis article/video repository in the world!