Clinical Endocannabinoid Deficiency

In 2004, about 12 years following the discovery of the endocannabinoid system (ECS), a theory regarding the existence of an endocannabinoid deficiency syndrome was published in a research paper entitled "Clinical Endocannabinoid Deficiency (CECD): Can This Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome, and Other Treatment-Resistant Conditions?"

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