Nanoemulsion Research

Updated: May 7

Although a relatively new technology, serious peer-reviewed research study reports have begun to emerge regarding nanoemulsion technology and how it might be employed in the burgeoning cannabis industry.

The following study results consistently demonstrate a greater bioavailability, including faster onset and increased peak potency, afforded by nanoemulsion preparation and delivery of a variety of compounds, including CBD.


A 2019 study entitled "Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol" that was published in the journal Medical Cannabis and Cannabinoids observed the relatively poor bioavailability of CBD when ingested orally. "Cannabidiol (CBD) is highly lipophilic [fat loving], and its oral bioavailability is known to be very low in humans."


The study's authors observed that their study was "the first to develop a CBD-based nanoemulsion formulation for testing, which they observed to "extensively enhance the absorption of CBD and improve its bioavailability."

The study developed a novel nanoemulsion preparation of CBD involving a droplet size of approximately 35 nm "to improve the poor solubility and absorption of CBD." The research reported that significant improvements in bioavailability were afforded by the nanoemulsification process. The period to achieve peak bioavailability (delay from time of consumption) was shortened by 330 percent and its potency was increased by 65 percent compared to a traditional non-nanoemulsified CBD oil.


The study's authors observed that their study was "the first to develop a CBD-based nanoemulsion formulation for testing, which they observed to "extensively enhance the absorption of CBD and improve its bioavailability."

A 2019 study entitled "Quercetin Loaded Nanoemulsion-based Gel for Rheumatoid Arthritis: In Vivo and In Vitro Studies" that was published in the journal Biomedicine & Pharmacotherapy explored the advantages of a topical application for treatment of arthritis.


The study found the nanoemulsified gel to feature improved bioavailability and "confirmed adequate rheological behavior with a good texture profile and improved drug permeation.” The study concluded that the nanoemulsified gel featuring the flavonoid quercetin "is an efficient topical treatment strategy for rheumatoid arthritis."


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