β-Sitosterol Research

Updated: May 7

The following homework sample from the Higher Learning LV course Understanding Flavonoids. It provides students with a brief overview of the peer-reviewed scientific research studies that have revealed the beneficial medicinal properties of this flavonoid that is produced by cannabis/hemp/marijuana.


The β-Sitosterol molecule


β-Sitosterol is a flavonoid that is produced by cannabis that has demonstrated the ability to reduce inflammation and may be effective in the treatment of rheumatoid arthritis. It has also been found to deliver neuroprotective efficacy that may reduce the severity of—or even prevent—cranial aneurysms. This flavonoid also functions as an antibacterial agent.


β-Sitosterol is a flavonoid that is produced by cannabis that has demonstrated the ability to reduce inflammation and may be effective in the treatment of rheumatoid arthritis.

A 2019 study entitled "β-sitosterol Modulates Macrophage Polarization and Attenuates Rheumatoid Inflammation" that was published in the journal Pharmaceutical Biology explored the efficacy of β-sitosterol on "immune-regulation on macrophages and its potential for rheumatoid arthritis therapy."


The study reported that injection with β-sitosterol "could alleviate the symptoms of ankle swelling" and "inhibit the production of pro-inflammatory cytokines." The researchers concluded that their results "suggested that β-sitosterol could modulate the functions of macrophages and might be a promising agent for rheumatoid arthritis therapy."

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A 2019 study entitled "β-Sitosterol Attenuates the Intracranial Aneurysm Growth" that was published in the journal Pharmacology noted that "it has been documented well that β-sitosterol has protective effects on various brain-related diseases."


The preclinical study found that rats treated with β-sitosterol "exhibited a significant reduction in aneurysmal size compared with control rats." It also found that this flavonoid reduced inflammation via a reduction in "the expression of chemokines and inflammatory cytokines."


The researchers concluded that "treatment with β-sitosterol suppresses the development [and severity] of intracranial aneurysms by inhibiting inflammatory reactions."


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