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Study: THCB & CBDB Isolated & Explained

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Study: THCB & CBDB Isolated & Explained

Study: THCB & CBDB Isolated & Explained. A 2020 study entitled "Isolation of a High-Affinity Cannabinoid for the Human CB1 Receptor from a Medicinal Cannabis sativa Variety: Δ9-Tetrahydrocannabutol, the Butyl Homologue of Δ9-Tetrahydrocannabinol" that was published in the Journal of Natural Products explored various characteristics of a chemical cousin of delta-9 THC called tetrahydrocannabutol, or THCB.

THCB joins the alphabet soup of cannabinoids
THCB joins the alphabet soup of cannabinoids

The researchers isolated the THCB molecule from the flower of a cannabis plant and applied the latest technology and investigative methods to learn more about this cannabinoid. The scientists explained that THCB displays a molecular binding affinity, or attraction, for the human CB1 and CB2 receptors "comparable to that of delta-9 THC."


Adding to the alphabet soup that is the modern world of marijuana- and hemp-derived cannabinoids, the study also identified a "B" variant of cannabidiol (CBD). In addition, it reported on the acidic precursors that result in CBDB and THCB, CBDBA and THCBA, respectively.

A single cannabis leaf.
Will the cannabis industry embrace THCB?

Study: THCB & CBDB Isolated & Explained Abstract

The abstract from this study appears below.


"The butyl homologues of Δ9-tetrahydrocannabinol, Δ9-tetrahydrocannabutol (Δ9-THCB), and cannabidiol, cannabidibutol (CBDB), were isolated from a medicinal Cannabis sativa variety (FM2) inflorescence. Appropriate spectroscopic and spectrometric characterization, including NMR, UV, IR, ECD, and HRMS, was carried out on both cannabinoids.


"The homologue of Δ9-THC, Δ9-THCB, showed an affinity for the human CB1 and CB2 receptors comparable to that of Δ9-THC."

"The chemical structures and absolute configurations of the isolated cannabinoids were confirmed by comparison with the spectroscopic data of the respective compounds obtained by stereoselective synthesis. The butyl homologue of Δ9-THC, Δ9-THCB, showed an affinity for the human CB1 (Ki = 15 nM) and CB2 receptors (Ki = 51 nM) comparable to that of (−)-trans-Δ9-THC. Docking studies suggested the key bonds responsible for THC-like binding affinity for the CB1 receptor.

A scientific graph of the cannabinoid THCB.
The study isolated and explained THCB

"The formalin test in vivo was performed on Δ9-THCB in order to reveal possible analgesic and anti-inflammatory properties. The tetrad test in mice showed a partial agonistic activity of Δ9-THCB toward the CB1 receptor."


View the original study.

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