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Deep Dive: The Endocannabinoid System & Depression

Updated: Mar 6, 2023

This Deep Dive serves two roles: First as a homework assignment for the Cannabis Foundation: Part 1 course and second as part of Higher Learning's Deep Dive Subscription.

For Deep Dive subscribers: This Deep Dive serves as a research review involving eight scientific investigations on this topic. This article is a living document that is updated regularly based on the release of new research about CBD for arthritis.

For students of Cannabis Foundation: Part 1, welcome to the third homework assignment for Module 1: Cannabis 1 > Lesson 5: Endocannabinoid System. This assignment summarizes a 2021 peer-reviewed scientific investigation about the relationship between the endocannabinoid system and depression.


A December 2021 research study entitled "Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression" that was published in the journal Frontiers in Pharmacology summarized existing literature and prior studies regarding "the role of the endocannabinoid system in depression" with the goal of including this information in "a holistic picture for a better understanding of the relationship between the two."

"The present review aims to provide a concise overview of the existing knowledge on the endocannabinoid system and its influence on the development of [depression]," declared the study.

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